Quick answers to common questions about organoid testing

About the Test

What exactly is organoid testing?

Organoid testing grows miniature versions of your tumor in a laboratory and tests many different cancer drugs to see which ones work best against your specific cancer cells.

It's like a "practice run" for your treatment—we find out what works before you receive it.

How is this different from genetic testing?

Genetic (genomic) testing reads your tumor's DNA to find mutations.
Organoid testing actually tests how your tumor responds to drugs.

Example:

  • Genetic testing might show you have a BRCA mutation
  • Organoid testing shows whether PARP inhibitors (the drugs that should work for BRCA) actually do work for your specific tumor

We integrate both types of data for the most complete picture.

Is this experimental?

No. Organoid technology has been validated in thousands of patients across dozens of peer-reviewed studies. It's been shown to predict treatment outcomes with 87-96% accuracy.

While it's newer than genetic testing, it's based on solid science and real clinical outcomes.

Which cancers can be tested?

Currently, OncoForma focuses on solid tumors, including:

  • Colorectal cancer
  • Pancreatic cancer
  • Ovarian cancer
  • Gastric cancer
  • Breast cancer
  • Lung cancer
  • Other solid tumors (case-by-case basis)

Blood cancers (leukemias, lymphomas) require different approaches and aren't currently offered.

The Process

Do I need an extra biopsy?

Usually no. We use tissue from biopsies or surgeries you're already having for your diagnosis or treatment.

In rare cases where additional tissue is needed, your doctor will discuss whether another biopsy is appropriate.

Does it hurt?

The organoid test itself is painless—it happens in a laboratory, not on you.

If tissue collection requires a procedure, any discomfort would be the same as your standard biopsy or surgery. The organoid test adds no extra pain.

How long does it take?

4-6 weeks from sample collection to results:

  • 7-14 days: Growing organoids
  • 7-10 days: Testing drugs
  • 2-3 days: Analyzing and reporting

This is fast enough to guide your initial treatment decision.

What if my organoids don't grow?

This happens in 5-15% of cases. If organoids don't grow successfully:

  • No charge for the unsuccessful attempt
  • Your doctor can consider retrying with another sample
  • You can proceed with other testing methods

Can I see my organoids?

While we don't typically share microscopy images directly with patients, your oncologist receives detailed information about how your organoids grew and responded to treatment.

If you're curious, ask your doctor—we're happy to share educational images!

Results and Treatment

What will the results tell me?

Your oncologist will receive a report showing:

Highly Sensitive:
Drugs that strongly killed or stopped your tumor cells

Moderately Sensitive:
Drugs with some effectiveness

Resistant:
Drugs unlikely to help

The report also explains how this fits with any genetic testing you've had.

Does this guarantee my treatment will work?

No test can guarantee treatment success, but organoid testing dramatically improves the odds.

Studies show 87-96% correlation between organoid responses and patient outcomes—meaning if your organoids respond well to a drug, you're very likely to as well.

What if the recommended drug isn't standard treatment?

Your oncologist will discuss all options with you, including:

  • Whether off-label use is appropriate
  • Clinical trials for promising drugs
  • Insurance coverage considerations
  • Risk-benefit balance

The test doesn't make treatment decisions—it gives you and your doctor better information to make those decisions together.

Can results change my prognosis?

Organoid testing helps identify the most effective treatment, which can improve outcomes. Studies have shown patients receiving organoid-guided therapy lived longer than those on standard approaches alone.

However, every cancer and every patient is unique. Your oncologist can best discuss your specific prognosis.

Cost and Insurance

How much does it cost?

Costs vary depending on insurance coverage, typically ranging from $5,000-8,000 for the full screening panel.

We provide cost estimates before testing so there are no surprises.

Does insurance cover this?

Coverage is evolving:

  • Some insurers cover functional testing for advanced cancers
  • Coverage may depend on your specific situation
  • We can help verify your benefits before testing

Our billing team will work with you to understand your coverage and out-of-pocket costs.

What if I can't afford it?

We offer:

  • Payment plans
  • Financial assistance programs (based on need)
  • Information about cancer-specific grants and foundations

Financial concerns should never prevent you from exploring this option. Contact us to discuss your situation.

Is it worth the cost?

Consider this: A single round of ineffective chemotherapy can cost $30,000-50,000, plus side effects and disease progression.

Studies show organoid testing saves an average of $47,000 per patient by avoiding ineffective treatments.

The question isn't whether you can afford the test—it's whether you can afford not to have it.

Safety and Privacy

Is my sample safe during shipping and testing?

Yes. Samples are:

  • Packaged in specialized medical-grade containers
  • Shipped via secure courier
  • Tracked throughout the process
  • Handled in certified laboratories following strict protocols

What happens to my sample after testing?

Samples are either:

  • Destroyed after testing (most common), or
  • Stored (with your permission) for potential future research or re-testing

You control what happens to your tissue.

Is my information private?

Absolutely. We follow HIPAA regulations and maintain strict privacy protections:

  • Your data is encrypted and secure
  • Only your medical team sees identified results
  • Research data is de-identified
  • You control who has access

Eligibility and Access

Can anyone get this test?

Organoid testing is most appropriate for:

  • Patients with confirmed cancer diagnoses
  • Situations where multiple treatment options exist
  • Advanced or metastatic disease
  • Recurrent cancer after prior treatment
  • Rare cancers with limited data

Your oncologist will help determine if it's right for you.

What if my doctor hasn't heard of this?

That's okay—organoid testing is relatively new to clinical practice, though well-established in research.

We offer:

  • Educational materials for physicians
  • Direct consultation with our medical team
  • Published research demonstrating efficacy
  • Support for physicians considering this test

We can help educate your medical team about how organoid testing might benefit you.

Can I request this test on my own?

Organoid testing requires a physician order and coordination with your medical team.

Start the conversation with your oncologist. We provide resources to help you discuss whether this test is appropriate for your situation.

Download our discussion guide →

What if I live far from your lab?

Distance isn't a barrier. We work with patients and physicians across North America:

  • Samples ship safely via specialized courier
  • Results delivered electronically to your oncologist
  • Remote consultations available

Scientific Questions

How accurate is organoid testing?

Multiple studies show 87-96% concordance between organoid drug responses and patient clinical outcomes.

This means if your organoids are sensitive to a drug, there's an 87-96% chance you will be too.

See the clinical evidence →

Why don't organoids work for every patient?

Occasionally (5-15% of cases), tumor cells don't grow well in laboratory conditions. This can happen due to:

  • Sample quality issues
  • Certain tumor types being harder to culture
  • Technical challenges

Success rates are improving as technology advances.

Can organoids predict immunotherapy responses?

This is an active area of research. Current organoid models are best for:

  • Chemotherapy
  • Targeted therapy
  • Some hormonal therapies

Immunotherapy prediction is more complex and still being refined.

Still Have Questions?

We're here to help.

📧 Email: patients@oncoforma.com
📞 Phone: [Phone number]
💬 Live Chat: [Available on website]

Or download our comprehensive patient guide:
Download PDF Guide →

No question is too small. Your understanding and comfort matter to us.